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SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.4
USERS' SCORE
Good
Based on 35 Reviews
8.8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B₁₂ (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
0
Vitamin B12 ineffective for CFS
N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports.
Direct evaluation of treatment effects
We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
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8
Vitamin B12 drops show promise
Open Trial of Vitamin B12 Nasal Drops in Adults With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Comparison of Responders and Non-Responders.
Direct investigation of B12 treatment
We examined the impact of vitamin B12 nasal drops on individuals suffering from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Our study involved fifty-one patients, predominantly female, with an average age of 42 and an average illness duration of 16 years.
After three months of treatment, we measured their vitamin B12 serum levels, physical activity, and fatigue and concentration levels. Interestingly, we found that the participants who responded positively to the treatment experienced significant improvements in their vitamin B12 levels, daily step count, and overall physical activity. Moreover, those who reported a positive response noted a decrease in fatigue levels.
On the flip side, those categorized as non-responders had only a modest increase in vitamin B12 levels, with no notable improvement in other measures. Overall, our findings suggest that nasal drops could serve as a viable alternative to vitamin B12 injections, especially since around two-thirds of participants reported feeling better after treatment. This pilot study opens up new avenues for interventions in managing ME/CFS and highlights the importance of considering alternative treatment methods.
After three months of treatment, we measured their vitamin B12 serum levels, physical activity, and fatigue and concentration levels. Interestingly, we found that the participants who responded positively to the treatment experienced significant improvements in their vitamin B12 levels, daily step count, and overall physical activity. Moreover, those who reported a positive response noted a decrease in fatigue levels.
On the flip side, those categorized as non-responders had only a modest increase in vitamin B12 levels, with no notable improvement in other measures. Overall, our findings suggest that nasal drops could serve as a viable alternative to vitamin B12 injections, especially since around two-thirds of participants reported feeling better after treatment. This pilot study opens up new avenues for interventions in managing ME/CFS and highlights the importance of considering alternative treatment methods.
Read More
7
We explored the effect of vitamin B12 on individuals diagnosed with chronic fatigue syndrome. The study focused on assessing how this vitamin might alleviate the symptoms associated with the condition. While many participants underwent concurrent treatments, which complicates isolating vitamin B12's specific impact, the research still provides insightful data.
Participants were monitored to see if vitamin B12 made a notable difference in fatigue levels and overall well-being. However, it appeared that the results were not overwhelmingly positive. The concurrent treatments among participants diluted our ability to assess the true effectiveness of vitamin B12 on its own, leading to an inconclusive outcome.
While we acknowledge the interest in vitamin B12 as a potential remedy for chronic fatigue syndrome, the findings suggest no significant benefits can be attributed to it directly. More focused research might be necessary to fully understand how—or if—vitamin B12 can support those dealing with this challenging syndrome.
Participants were monitored to see if vitamin B12 made a notable difference in fatigue levels and overall well-being. However, it appeared that the results were not overwhelmingly positive. The concurrent treatments among participants diluted our ability to assess the true effectiveness of vitamin B12 on its own, leading to an inconclusive outcome.
While we acknowledge the interest in vitamin B12 as a potential remedy for chronic fatigue syndrome, the findings suggest no significant benefits can be attributed to it directly. More focused research might be necessary to fully understand how—or if—vitamin B12 can support those dealing with this challenging syndrome.
Read More
Most Useful Reviews
9.5
Reduced fatigue
Good vitamins; as recommended by my doctor for the nervous system and reducing fatigue, they accomplished just that. I highly recommend purchasing them.
Read More
9.5
Syndrome relief
I initially took these vitamins for restless leg syndrome, which improved drastically within a month. Doctors recommend such supplements in older age to combat poor digestion. If my review has been helpful, please click the Yes button below.
Read More
9.5
Mood improvement
After years of being vegetarian, I realised my mood was suffering due to a lack of vitamin B12. I began taking these supplements, and I no longer feel fatigued or depressed. The methyl B12's absorption was just what I needed.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.4
8
Vitamin B12 drops show promise
Open Trial of Vitamin B12 Nasal Drops in Adults With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Comparison of Responders and Non-Responders.
Direct investigation of B12 treatment
We examined the impact of vitamin B12 nasal drops on individuals suffering from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Our study involved fifty-one patients, predominantly female, with an average age of 42 and an average illness duration of 16 years.
After three months of treatment, we measured their vitamin B12 serum levels, physical activity, and fatigue and concentration levels. Interestingly, we found that the participants who responded positively to the treatment experienced significant improvements in their vitamin B12 levels, daily step count, and overall physical activity. Moreover, those who reported a positive response noted a decrease in fatigue levels.
On the flip side, those categorized as non-responders had only a modest increase in vitamin B12 levels, with no notable improvement in other measures. Overall, our findings suggest that nasal drops could serve as a viable alternative to vitamin B12 injections, especially since around two-thirds of participants reported feeling better after treatment. This pilot study opens up new avenues for interventions in managing ME/CFS and highlights the importance of considering alternative treatment methods.
After three months of treatment, we measured their vitamin B12 serum levels, physical activity, and fatigue and concentration levels. Interestingly, we found that the participants who responded positively to the treatment experienced significant improvements in their vitamin B12 levels, daily step count, and overall physical activity. Moreover, those who reported a positive response noted a decrease in fatigue levels.
On the flip side, those categorized as non-responders had only a modest increase in vitamin B12 levels, with no notable improvement in other measures. Overall, our findings suggest that nasal drops could serve as a viable alternative to vitamin B12 injections, especially since around two-thirds of participants reported feeling better after treatment. This pilot study opens up new avenues for interventions in managing ME/CFS and highlights the importance of considering alternative treatment methods.
Read More
8
B12 may aid chronic fatigue treatment
Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia.
Relevant score suggests moderate support
We explored the effects of frequent vitamin B12 injections in patients suffering from chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME). The study included 38 patients who received B12 injections at least weekly for a period ranging from six months to several years.
Our findings revealed two groups of patients: those termed "Good responders" and "Mild responders." Good responders, who reported feeling significantly better, used higher doses and more frequent injections of B12, alongside daily oral folic acid tailored to their individual needs.
Interestingly, the results indicated that Mild responders often relied on pain medications like opioids, which might interfere with B12’s effects. We noted that co-existing thyroid issues were common among these patients, suggesting a complex interaction at play.
Overall, our study points to a real potential benefit from vitamin B12 and folic acid in managing chronic fatigue symptoms. However, individual responses can vary greatly, and it’s crucial to consider each patient's unique circumstances when designing future clinical studies.
Our findings revealed two groups of patients: those termed "Good responders" and "Mild responders." Good responders, who reported feeling significantly better, used higher doses and more frequent injections of B12, alongside daily oral folic acid tailored to their individual needs.
Interestingly, the results indicated that Mild responders often relied on pain medications like opioids, which might interfere with B12’s effects. We noted that co-existing thyroid issues were common among these patients, suggesting a complex interaction at play.
Overall, our study points to a real potential benefit from vitamin B12 and folic acid in managing chronic fatigue symptoms. However, individual responses can vary greatly, and it’s crucial to consider each patient's unique circumstances when designing future clinical studies.
Read More
8
Potential effects on chronic fatigue
Treatment of multiple sclerosis with lofepramine, L-phenylalanine and vitamin B(12): mechanism of action and clinical importance: roles of the locus coeruleus and central noradrenergic systems.
Combination therapy complicates evaluation
We recently came across an intriguing study that highlighted the potential benefits of a combination therapy involving lofepramine, L-phenylalanine, and vitamin B12 for patients suffering from multiple sclerosis (MS). Conducted as a randomized, placebo-controlled double-blind trial, the research aimed to evaluate how this combination could help alleviate various symptoms associated with MS and chronic pain.
While this study did address the role of vitamin B12, it was examined alongside lofepramine and phenylalanine. This makes it challenging for us to pinpoint the specific impact of vitamin B12 in the context of chronic fatigue syndrome on its own. The treatment showed effectiveness in improving symptoms within just two to four weeks, but due to the combination of treatments, we need more focused studies to assess vitamin B12's distinct role.
Overall, it's exciting to see a potential link between this therapy and symptom relief, yet we must remain cautious about attributing the benefits solely to vitamin B12, given the blended approach of the therapy used in the trial.
While this study did address the role of vitamin B12, it was examined alongside lofepramine and phenylalanine. This makes it challenging for us to pinpoint the specific impact of vitamin B12 in the context of chronic fatigue syndrome on its own. The treatment showed effectiveness in improving symptoms within just two to four weeks, but due to the combination of treatments, we need more focused studies to assess vitamin B12's distinct role.
Overall, it's exciting to see a potential link between this therapy and symptom relief, yet we must remain cautious about attributing the benefits solely to vitamin B12, given the blended approach of the therapy used in the trial.
Read More
7
We explored the effect of vitamin B12 on individuals diagnosed with chronic fatigue syndrome. The study focused on assessing how this vitamin might alleviate the symptoms associated with the condition. While many participants underwent concurrent treatments, which complicates isolating vitamin B12's specific impact, the research still provides insightful data.
Participants were monitored to see if vitamin B12 made a notable difference in fatigue levels and overall well-being. However, it appeared that the results were not overwhelmingly positive. The concurrent treatments among participants diluted our ability to assess the true effectiveness of vitamin B12 on its own, leading to an inconclusive outcome.
While we acknowledge the interest in vitamin B12 as a potential remedy for chronic fatigue syndrome, the findings suggest no significant benefits can be attributed to it directly. More focused research might be necessary to fully understand how—or if—vitamin B12 can support those dealing with this challenging syndrome.
Participants were monitored to see if vitamin B12 made a notable difference in fatigue levels and overall well-being. However, it appeared that the results were not overwhelmingly positive. The concurrent treatments among participants diluted our ability to assess the true effectiveness of vitamin B12 on its own, leading to an inconclusive outcome.
While we acknowledge the interest in vitamin B12 as a potential remedy for chronic fatigue syndrome, the findings suggest no significant benefits can be attributed to it directly. More focused research might be necessary to fully understand how—or if—vitamin B12 can support those dealing with this challenging syndrome.
Read More
7
Vitamin B12's role in fatigue
Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome.
Study highlights vitamin B12's importance
We observed that a group of twelve outpatients, all women diagnosed with both fibromyalgia and chronic fatigue syndrome, participated in a study focused on understanding the role of vitamin B12 in their condition. While most of their blood lab results were normal, one significant finding stood out: all patients had elevated levels of homocysteine in their cerebrospinal fluid.
The study found a noteworthy link between these increased homocysteine levels and the degree of fatigue experienced by the patients. Moreover, low levels of vitamin B12 in the cerebrospinal fluid were correlated with feelings of fatigue, suggesting that vitamin B12 might play a vital role in how these patients feel day-to-day.
The researchers concluded that the elevation of homocysteine in the central nervous system could be indicative of fibromyalgia and chronic fatigue syndrome. They suggested that a deficiency in vitamin B12 might hinder the body's ability to regulate homocysteine, contributing to the symptoms of fatigue these patients experience. However, while vitamin B12 is shown to be important in this context, the study does not specifically isolate its effects from other contributing factors or treatments.
The study found a noteworthy link between these increased homocysteine levels and the degree of fatigue experienced by the patients. Moreover, low levels of vitamin B12 in the cerebrospinal fluid were correlated with feelings of fatigue, suggesting that vitamin B12 might play a vital role in how these patients feel day-to-day.
The researchers concluded that the elevation of homocysteine in the central nervous system could be indicative of fibromyalgia and chronic fatigue syndrome. They suggested that a deficiency in vitamin B12 might hinder the body's ability to regulate homocysteine, contributing to the symptoms of fatigue these patients experience. However, while vitamin B12 is shown to be important in this context, the study does not specifically isolate its effects from other contributing factors or treatments.
Read More
User Reviews
USERS' SCORE
Good
Based on 35 Reviews
8.8
9.5
Reduced fatigue
Good vitamins; as recommended by my doctor for the nervous system and reducing fatigue, they accomplished just that. I highly recommend purchasing them.
9.5
Syndrome relief
I initially took these vitamins for restless leg syndrome, which improved drastically within a month. Doctors recommend such supplements in older age to combat poor digestion. If my review has been helpful, please click the Yes button below.
9.5
Mood improvement
After years of being vegetarian, I realised my mood was suffering due to a lack of vitamin B12. I began taking these supplements, and I no longer feel fatigued or depressed. The methyl B12's absorption was just what I needed.
9.5
Fatigue alleviation
I discovered my B12 levels were low after six years of being a vegan. By taking these supplements, the 'muscular fatigue' I felt disappeared after just three days. I wish I had started this sooner; the impact is remarkable.
9.5
Enhanced well-being
The effect was tremendous! I feel mentally stable, and my muscle fatigue along with shoulder stiffness lessened. It even helped with my eye strain headaches. I’m truly amazed by its effectiveness at this price!
